… that celecoxib is effective in the advanced stages of cancer. … survival of patients in prostate,
cervical, skin, and bladder cancer. … Phase I/II, III/IV clinical trials in collaboration with NCI and …

… cells in the tumor microenvironment (TME), promoting cancer … synthase 1 (PTGS1), and
cyclooxygenase-2 (COX-2), officially … For example, celecoxib was shown to inhibit HCC cell …

… carcinogenesis, as well as the involvement of cyclooxygenase-2 (… COX-2 Tumor
microenvironment and inflammation Cancer … that treating cervical cancer patients with celecoxib …

… the tumour microenvironment (TME) supports cancer cell … ) in a phase I/II trial involving
patients with metastatic melanoma (… treatment with the NSAID COX2 inhibitor celecoxib. PGE 2 –…

… and its metabolites as biomarkers for screening of gastric cancer. Deng et al. indicated
that … in tumor cells. Thereafter, high level of kynurenine in the tumor microenvironment is …

… the development of cancer. The microenvironment surrounding the tumor is greatly influenced
… 1-alpha through the activation of cyclooxygenase-2 and the NF-кB inflammatory signaling …

… acts on the tumor microenvironment to increase the production of … The COX-2 inhibitor
celecoxib enhanced the efficacy of … cancers because it has a potential as a disease biomarker and …

… of an immunosuppressive tumor microenvironment (TME) by … trial, a phase I-II study testing
the COX-2 inhibitor celecoxib … to secrete cyclooxygenase 2 (COX-2) and induce cancer stem …

… Cyclooxygenase-2 inhibitor studies in animal models have thrown light on its role in … %,
respectively, in cervical cancer patients receiving chemo-radiotherapy treated with celecoxib [20] …

… of the microbiome and the tumor microenvironment [9]. … skin cancer, melanoma in situ,
Stage I cervical cancer, or … III colon cancer patients to a 3 year intervention of celecoxib or …